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Top 10 Fictional TV Drugs

VO: Rebecca Brayton
Script written by Garrett Alden They're the drugs from the small screen that we either wish were real, or are really glad don't exist. Join as we count down our picks for the top 10 fictional drugs from TV. For this list, we'll be taking into account the medicines, narcotics, and other compounds that are the most inventive, interesting, iconic, or important to the shows in question. Let's begin! Special thanks to our user LumiLys for submitting the idea using our interactive suggestion tool at WatchMojo.comsuggest

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Script written by Garrett Alden

Top 10 Fictional TV Drugs

They’re the drugs from the small screen that we either wish were real, or are really glad don’t exist. Welcome to and today we’re counting down our picks for the top 10 fictional drugs from TV.

For this list, we’ll be taking into account the medicines, narcotics, and other compounds that are the most inventive, interesting, iconic, or important to the shows in question. Let’s begin!

#10: Riderall
“It’s Always Sunny in Philadelphia” (2005-)

Let’s start with a substance a little close to reality – Riderall. An apparent combination of Ritalin and Adderall, it’s the go-to upper for the frat members of Dennis’ old fraternity, as the gang at Paddy’s Pub discovers. Although the whole group is no stranger to many forms of substance abuse, it’s Dennis and Frank who partake in the snorting of Riderall while they attempt to recruit some help for the Flipadelphia competition at the frat. After being tased, the pair then takes Riderall-fueled revenge on the frat boys, culminating with a message left in flaming letters on the lawn.

#9: Nomolestol
“The Venture Bros.” (2003-)

When the only man willing to be a bodyguard to you and your two sons is your former archenemy and a pedophile, who has allegedly molested said boys by the way, then the answer to your problems is Nomolestol! Sergeant Hatred’s drug of choice was developed by his former employers at the Office of Secret Intelligence to allow the profoundly disturbed man to perform his job protecting the Venture family by keeping his urges in check. The withdrawal symptoms can be pretty severe though, including sweats, dark thoughts, growing large breasts, and the desire to drink men’s fragrance products.

#8: Hydromel
“Doctor Who” (1963-)

Although hydromel is the French name for mead, the one featured in the Whoniverse is far from honey water! This phosphorescent compound staves off the effects of Lazars’ Disease, which is similar to leprosy. The sufferers are transported to the Terminus space station, where hydromel is supplied to the enslaved work force that runs it. These guards are called the Vanir and the hydromel they’re given helps them to stay healthy. If they stop taking it however, they risk becoming Lazars themselves, and that’s obviously not the most ideal situation.

#7: Luck Virus
“Red Dwarf” (1988-99; 2009; 2012-)

You’d think with all the viruses out there, there’d be a couple that could affect people positively, right? And as Dr. Hildegard Lanstrom, and the boys from Red Dwarf, discover, there are, and they can be packaged in liquid form! One among them is the luck virus, which people apparently contract for small periods throughout their lives. In concentrated form, luck can make the implausible and unlikely come true, like picking cards out of a deck or typing out the right combination on a keypad at random. Luck also acts as a counteragent to another positive virus: sexual magnetism.

#6: NZT-48
“Limitless” (2015-)

Sometimes, you need a double dosage of a drug. NZT-48 made our Top Fictional Movie Drugs list as well, but since it’s so integral to the show (which is based on the movie that was based on a book anyway), we’re going to expound the merits, and the costs, of the brainpower boosting pill once more. The show centers on Brian Finch, whose introduction to the smart drug leads him into a job with the FBI and a connection to Bradley Cooper’s character from the film, Eddie Morra, who’s now a shady senator. Although Morra supplies Brian with a drug that counters NZT’s harmful side effects, Brian’s work, and his acquaintance with the senator, bring their own risks…

#5: Bloody Eye [aka Red Eye]
“Cowboy Bebop” (1998-99)

A designer steroid-like drug created by the interplanetary crime network simply called “the Syndicate,” Bloody Eye is appropriately administered through eye spray, tinting the user’s eyes red and giving a crimson tinge to their vision. Like most steroids, it enhances physical strength. In addition, Red Eye heightens awareness to the point where everything seems to move slower than it really does, allowing for quicker reactions. It doesn’t help if the user can’t see their opponent’s blows coming, however. Red Eye’s side effects may also include increased aggression and difficulty breathing, likely because of the demand it puts on the body.

#4: Focusyn
“The Simpsons” (1989-)

A series as satiric as “The Simpsons” is bound to invent a few drugs for its purposes, both legal and otherwise, whether it’s the fictitious Flintstones Chewable Morphine or the memory-altering Repressitol. Our pick, Focusyn, is recommended by Principal Skinner to treat ADD. When Bart’s antics go too far, Marge guilt trips her son into trying it. While it seems to work fine initially, Bart soon becomes paranoid; believing that satellites owned by Major League Baseball are spying on him. However, since MLB satellites really are monitoring everyone, the drug’s actual merits are debatable. It’s clearly not for everyone though, as evidenced by Homer’s extremely twitchy reaction.

#3: Chemical X
“The Powerpuff Girls” (1998-2005)

Besides sugar, spice, and everything nice, Chemical X is what makes the Powerpuff Girls so, well, powerful. A sort of catch all mutagen, the black, opaque liquid is a recurring plot device, often giving rise to villains of the week, as well as some of the trio’s most ardent foes, such as Mojo Jojo, who received his increased intellect and green skin in the same accident that created the adorable, titular superheroes. You’d think with all the mayhem it’s caused, Professor Utonium would keep it under better guard.

#2: Vitameatavegamin
“I Love Lucy” (1951-57)

In what may be one of the most well-known episodes of “I Love Lucy,” Lucy manages to finagle her way into appearing as a spokeswoman for a TV commercial. The ad is for Vitameatavegamin, a health tonic, containing vitamins, minerals, meat, and vegetables; everything a body needs. As Lucy and the director soon discover however, it also contains twenty-three percent alcohol. After sampling it several times for numerous takes, Lucy becomes progressively sloshed and slurs her way through the sales pitch, memorably mispronouncing the many-syllabled product’s name.

Before we reveal our number one pick, here are some honorable mentions:
- Vertigo
“Arrow” (2012-)
- Teamocil
“Arrested Development” (2003-06; 2013-)
- E-Z Doze-It Sleeping Pills
“Looney Tunes” franchise (1930-)
- Totally Awesome Sweet Alabama Liquid Snake
“Metalocalypse” (2006-13)

#1: Blue Sky
“Breaking Bad” (2008-13)

You said it, Jesse. After having to alter their cooking process, everyone’s favorite meth-making duo ends up with what becomes their signature product: Blue Sky. Behind the scenes, the blue coloring was designed by the writers to make sure Walt and Jesse’s meth was distinctive, but in reality blue meth, while possible, is unlikely to be as chemically pure as theirs is purported to be. Then again, the Big Blue, Blue Magic and Fring’s Blue, as it is also known, may just be further testament to the great Heisenberg’s chemistry skills.

Do you agree with our list? What’s your favorite fictional TV pharmaceutical? For more body chemistry altering Top 10s published daily, be sure to subscribe to

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