Michael J Fox, famous for Back To the Future and countless other roles, has Parkinsons and has helped raise hundreds of millions of dollars for the cause.
Bono, frontman of U2 has Glaucoma. As well as being one of the most famous rock stars alive he also played an acid dealer in the Beatles-based rock musical film Across The Universe.
RJ Mitte was not breathing at the time of his birth causing brain damage, has cerebal palsy but went on to be one of the stars of hit show Breaking Bad.
Marlee Matlin, deaf actress was in Judging Amy, ER, Seinfeld, The L Word and Nip/Tuck as well as many film roles. She was also on the panel for Donald Trump's Comedy Central Roast.
Warwick Davis, has dwarfism, starred in Star Wars: Return of the Jedi, Leprechaun, Labyrinth, Willow and Ricky Gervais's 'Life's Too Short' alongside Johnny Depp and Liam Neeson.