Apparently the scene from "The One with the Day After" was so emotional that David Schwimmer and Jennifer Aniston were left in tears even after they finished shooting the scene.
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Top 10 Most Emotional Break-Up Scenes on TV
#2
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Angel21
Glee - Finn and Rachel, Kurt and Blaine and Santana and Brittany
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#3
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Angel21
Grey's Anatomy - Dr. Preston Burke and Dr. Cristina Yang